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Data Report · Manganese

What Has Been Measured About Manganese and What Can Be Quoted

This compilation separates two things that are often confused in everyday life: the measured values from nutrition research and the statements that an EU regulation authorizes for labeling. One belongs to data, the other to legal text.

MG PER 100 G PRODUCT CATEGORIES

An Element More Abundant in Plants Than in Humans

Manganese is one of the most abundant metals in the Earth’s crust. For plants, it is a nutrient: they need it in particular in the water-splitting complex of photosynthesis, where four manganese atoms sit on a single structure. That is why plant foods have higher levels than animal foods, and why these levels vary with the soil the plant grew in.

Grains, Nuts, and a Leaf Infusion

The highest values among common foods are found in whole grains, legumes, hazelnuts, and — by a clear margin — dried tea leaves. With tea, note that it is not the leaf that is consumed but the infusion; the amount that ends up in the cup depends on steeping time and water hardness. Meat, fish, and dairy products, on the other hand, are at the bottom of the table.

Approximate manganese content per 100 grams of ready-to-eat food
FoodProduct categoryContent
Rolled oatsGrain product4.5 mg
Whole wheat breadBaked good2.0 mg
HazelnutsNuts5.5 mg
Dried soybeansLegume2.7 mg
Fresh pineappleFruit0.9 mg
Cooked spinachVegetable0.7 mg
Black tea, brewedBeverage0.3 mg
Lean beefMeat0.02 mg

Approximate values from French food composition tables. Data for a particular batch may differ.

Soil Origin and the Spread of Measured Values

Two tables can list different figures for the same food without either being wrong. A plant’s content depends on the availability of manganese in the soil, which varies by region: acidic soils release the element more readily than chalky soils. Added to this are variety, harvest date, the extraction rate for grains, and water loss during cooking. Reliable compilations therefore give ranges rather than single values and state the number of samples analyzed.


Absorption, Distribution, and an Exit Through the Liver

The amount on the plate and the amount that reaches the tissue are two different quantities. For manganese, the gap between them is large: studies using labeled isotopes arrive at an absorption rate of just a few percent in adults. The rest leaves the intestine without crossing the lining.

DMT1 Carries More Than Iron

The transporter that moves divalent metal ions across the brush-border membrane of the duodenum is called DMT1. It is not specific to a single element and accepts manganese, cobalt, and zinc in addition to iron. This creates competition: if the intestinal lumen contains a lot of iron, the share of manganese absorbed decreases, and vice versa. Phytates from grain hulls also bind the ion and hold it back — precisely in the foods with the highest levels.

The Store Is Distributed Among Liver, Bones, and Kidneys

What is absorbed first reaches the liver via the portal vein. From there, part of it enters the circulation, bound to plasma transport proteins, and is distributed to the bones, pancreas, kidneys, and brain. An adult’s total body store is on the order of a few milligrams — somewhere between a trace element and an ultra-trace element. Excretion occurs mainly through the bile. When intake rises, the liver increases this elimination; when it is low, the liver holds on. In this way the body keeps its store within a narrow range.

Reference Amounts for Daily Intake in Adults
Reference amountIssuing bodyValue
Nutrient reference value for labelingRegulation (EU) No 1169/20112.0 mg
Estimated value for adequate intakeANSES reference values2.0–5.0 mg
Adequate Intake (AI)European Food Safety Authority3.0 mg
Minimum amount for an authorized claim15 % of the reference value per serving0.3 mg

The nutrient reference value is used for labeling and does not represent an individual requirement. It falls under a different regulation than the authorized claims.


Three Enzyme Families Linked to the Authorizations

The European opinions do not base the authorized statements on observations in volunteers, but on the established function of the element in certain proteins. Three groups come up again and again.

Arginase in the Urea Cycle

This enzyme closes the cycle by which the liver converts ammonia into urea. Two manganese ions hold a water molecule at the active center and make it reactive; only then is arginine split. This assignment is well established in structural biology and appears in the opinions as evidence of involvement in amino acid metabolism.

Transfer Enzymes of the Ground Substance

In connective tissue and in the organic framework of bone, there are proteins with long sugar chains attached. The enzymes that extend these chains link by link work with a divalent metal ion that holds the sugar donor in place. Manganese fills this role in several of these enzymes. The claim relating to the maintenance of normal bones rests on this observation.

From Two Radicals, Oxygen and Hydrogen Peroxide Arise

In the inner matrix of the mitochondrion, cellular respiration continuously produces superoxide. The protective enzyme located there makes two of these molecules react with each other: one gives up its extra electron, the other takes it on. What remains is ordinary oxygen and hydrogen peroxide, which other enzymes then convert into water. At the center of this process is a manganese atom that alternates between two charge states while itself remaining intact.

“Manganese contributes to the protection of cells from oxidative stress”

Per Regulation (EU) No 432/2012


What an Authorization Settles and What It Leaves Open

Regulation (EU) No 432/2012 establishes a list of wordings that may be used on packaging and in advertising. It is a positive list: anything not on it may not be used as a health claim, even if it sounds plausible.

No Minimum Amount, No Statement on the Package

A claim comes with a condition. A product may only carry it if it contains, per serving or per 100 grams, at least a certain amount of the substance — derived from the nutrient reference value in the labeling regulation. If the content is lower, the right to use it lapses, regardless of how accurate the underlying biochemistry is.

Maintaining Is Not the Same as Increasing

The choice of words on the list is not accidental. “Maintenance” means keeping a normal state, not making it better. “Contribution” means taking part, not being the cause. And “normal” refers to the state of a healthy person, not to a set of symptoms. Anyone who reads these three words understands why the statements sound so restrained: they are worded exactly to the extent of the assessment.

The claims are addressed to the general population. They are neither a statement about any particular person, nor a recommendation to take anything, nor the promise of an effect.

Quoted Without Alteration

The three entries in the Union list relating to manganese, reproduced exactly as they appear there. Each entry stands on its own; they may not be combined or reworded.

  1. Manganese contributes to normal energy-yielding metabolism Per Regulation (EU) No 432/2012
  2. Manganese contributes to the maintenance of normal bones Per Regulation (EU) No 432/2012
  3. Manganese contributes to the protection of cells from oxidative stress Per Regulation (EU) No 432/2012

Dumortierreich: Questions Asked

Is manganese the same as magnesium?

No. The two names sound alike, the elements do not. Magnesium has the symbol Mg, belongs to the alkaline earth metals, and is measured in grams in adults. Manganese has the symbol Mn, belongs to the transition metals, and in terms of body store is several orders of magnitude lower. The authorized claims also differ: the list contains considerably more entries for magnesium than for manganese.

Is there an upper limit above which intake is considered a concern?

For manganese from the regular diet, no tolerable upper intake level has been set in Europe, as the data were judged too limited. This is not permission to take more, but a statement about the state of the data. Attention focuses mainly on highly dosed single-ingredient preparations and on occupational exposure through inhalation, which is not comparable to dietary intake. Questions about your own intake belong in a medical consultation.

Does the statement on cell protection also apply to visible skin aging?

No. The entry speaks of the protection of cells from oxidative stress and thus stays at the level of the cell. It contains no statement about the appearance of the skin, wrinkles, or the aging process as a whole, and such a statement would not be covered by the authorization.

How is it that drinking water is considered a source of manganese in some regions?

Manganese is released from manganese-bearing rock and can pass into groundwater. It is normally removed together with iron when drinking water is processed, since otherwise it causes brown discoloration and deposits in pipes; drinking-water rules set a limit for this. The contribution of tap water to daily intake is therefore generally small, but may differ for households supplied by a private well.

Why does the word “maintenance” appear in the claim about bone?

Because the assessment did not go any further. What is established is involvement in forming the ground substance in which bone mineral is deposited — that is, in maintaining existing tissue in its normal state. A statement about bone density, fractures, or building additional bone mass would be something else and is not part of the entry.


The Complete Data Report

What appears on this page is an excerpt. The paid edition has 74 pages: series of measurements by product category with the number of samples, intake values from several bodies side by side, the complete Q&A section, and a list of the opinions used, with references.

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The content of this website is general information about a trace element. It is neither medical advice, nor a diagnosis, nor instructions for self-medication. If you have symptoms or an existing illness, are pregnant or breastfeeding, and before taking dietary supplements, please consult a doctor’s office or a pharmacy. Dietary supplements are not a substitute for a varied diet and a healthy lifestyle. Follow the dose stated by the manufacturer and keep these products out of the reach of young children. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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